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Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal mediator that plays a role in the development and enlargement of the prostate gland. Dutasteride was approved by the FDA in 2001 for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men as monotherapy or in combination with the α-adrenergic antagonist tamsulosin to enhance the therapeutic response. Its clinical efficacy against benign prostate hyperplasia in male patients is comparable to that of finasteride, a specific type II 5α-reductase inhibitor. However, unlike finasteride, Dutasteride is not yet indicated for the treatment of androgenic alopecia although it was demonstrated to be effective in several randomized, double-blind, placebo-controlled trials in androgenetic alopecia.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Note: Women of childbearing potential should not use or handle dutasteride capsules. Dutasteride can cause birth defects in male fetuses.

Dutasteride is used alone or in combination with tamsulosin (Flomax) to treat men who have symptoms of an enlarged prostate gland, which is also known as benign prostatic hyperplasia (BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems with urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.

Dutasteride blocks the action of an enzyme called 5-alpha-reductase. This enzyme changes testosterone to another hormone that causes the prostate to grow. As a result, the size of the prostate is decreased. The effect of dutasteride lasts only as long as the medicine is taken. If it is stopped, the prostate begins to grow again.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule, Liquid Filled

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Patients have variable levels of participation in decision making related to vascular procedures and often consider their treatments unsuccessful. Both of these drugs caused translocation of PKC-delta from membranes to cytosol in adult but not in old rats. Splenectomy restores tumoricidal activity to promote elimination of intraocular tumors. Composition-solubility-structure relationships in calcium (alkali) aluminosilicate hydrate (C-(N,K-)A-S-H). The aim of this study was to introduce the MID for the Vascular Quality of Life Questionnaire (VascuQol) and the walking impairment questionnaire (WIQ) for patients with intermittent claudication (IC).

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The mismatch between explicit and implicit responsiveness to emotional cues was found both in behavioral variant FTD and in agrammatic variants of primary progressive aphasia. Convalescence was quick and there were no postoperative complications. Analysis of Navy Physical Evaluation Board diagnoses (1998-2000).

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Eight steps all dentists need to know about refining their scrap. A case of myocardial infarction in a young female with subclinical hyperthyroidism.

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Tribulin is endogenous monoamine oxidase and benzidiazepine binding inhibitory activity extractable from biological tissues and body fluids into ethyl acetate. Except for 4 fellow-doctors were infected by close contact in a same dormitory, all others were infected on work-station of close contact with SARS patients, there were no more cross-infection among the health care workers.

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At 48 h after insult, CSF levels of 14-3-3beta, 14-3-3zeta, and calpain cleavage products of alpha-spectrin and tau were quantified. Adequately powered longitudinal studies including formal neurocognitive and QOL assessments are needed to advance our understanding of the incidence of cognitive dysfunction and its impact on functional ability and QOL in ovarian cancer patients.

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From the results of different studies it is known that stereotyped images about ageing and elderly people frame and influence the attitudes, beliefs and activities of elderly people and also influence the interaction of others with elderly people. We compared demographic and clinical characteristics, and immunologic changes in patients with and without IRIS. Logistic regression showed that high tumor grade, Jackson stage and vascular endothelium growth factor-C immunoexpression were independent predictors of inguinal metastasis.

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Alternative, antibody-free techniques to western analysis of protein blots can offer reduced assay times for routine analysis of expression of recombinant proteins. The results suggest that patients attending general dental practices are representative of the general population both in terms of lesion prevalence and high risk habits such as smoking and drinking. In addition, although the GHR/GHBP gene transcription is down-regulated by supraphysiologic growth hormone concentrations, this effect was not found when GHBP levels were measured. Then, the concentrations of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA), 5-hydroxytryptophan (5-HTP) and dopa were measured in various brain regions. The theoretical and clinical implications of these results could lead to a shift in focus for studies of genetic disorders.

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These patients suffer physically and psychologically from this disorder, and thus there is a research interest in the condition. Locus specific PCR is performed generating two allelic products. Obstetric epidural analgesia: systemic analysis of an error of syringe rate programming

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Nine patients had low-grade lymphomas (five cases of gastric lymphoma, two patients with lymphoma arising in the lung, one parotid and one lacrimal gland lymphoma), while one patient had a high-grade gastric lymphoma arising from a low-grade background. The early transcriptional region 4 (E4) of adenovirus type 5 (Ad5) encodes gene products that modulate splicing, apoptosis, transcription, DNA replication, and repair pathways. We show that the compressive strength scales with tensile strength between cells but depends also on the friction coefficient and a parameter describing cell shape distribution.

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There have been no detailed analyses of the induction of donor cell-type chimerism, the onset and incidence of acute and chronic graft-versus-host disease (GVHD), and the immune recovery kinetics after reduced-intensity stem cell transplantation (RIST). Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Image quality of supine chest radiographs: intra-individual comparison of computed radiography and low-dose linear-slit digital radiography.

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A transcriptional imbalance in MS may contribute to immune dysregulation and neurodegeneration, and we identify HDAC inhibition as a transcriptional intervention to ameliorate this imbalance. A study of the importance of the dosage for the arousal of neuroleptic acute dystonias. Exposure to breast-feeding activities, assessed by maternal recall prior to discharge, was universally high at the program hospital and universally low at the control hospital. PG-specific T cell interleukin-2 (IL-2) production and B cell antibody responses were assessed. Hepatic inflammation is one of the most common features of DILI.

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Specificity of antinuclear and antiphospholipid antibodies in sera of patients with autoimmune lymphoproliferative disease (ALD). A cystoscopy was performed and showed metastases to the mucosa of the bladder. N1 and P2 amplitudes of the waking AEP declined after sleep in the HC group, but not in MDD. The immediate objective of this study was to perform a consensus validation of the community meeting as a prevention and intervention measure for assault.

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Cytoplasmic staining indicative of antisense riboprobe hybridization to P2Y(2) receptor mRNA was observed in the palpebral and bulbar conjunctival epithelium, including goblet cells, the corneal epithelium, and in meibomian gland sebaceous and ductal cells. Molecular epidemiology of Haemophilus influenzae type b isolated from children with clinical cases of conjugate vaccine failures. Effect of fluoride treatment on remineralization of bleached enamel.

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Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. By progressive condensation, presecretory granules matured into secretion granules that contained a densely packed SLS-like aggregate, within which individual crystallites were no longer discernable.

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To achieve high-level production of deoxycytidine, a useful precursor of decitabine, genes related to feed-back inhibition as well as the biosynthetic pathway were engineered. In a loss-of-function experiment, we further show that production and secretion of placental growth factor, but not vascular endothelial growth factor A in MSCs, were essential for the MSCs-induced neovasularization after cardiac muscle injury to facilitate cardiac muscle repair. We retrospectively investigated the relationship between the appearance of IS/OS line on OCT images and visual acuity after resolution of DME by vitrectomy.

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Significant differential adhesion is observed over the full complement of amino acids, determined largely by amino acid side-chain charge. Lumbar disk herniation is a commonly seen disorder that requires care by spinal surgeons and healthcare professionals. Plasma fibrinogens of sublethally irradiated rabbits (8 Gy X-ray irradiation) were isolated by affinity chromatography on fibrin monomer Sepharose and characterised by polyacrylamide gel electrophoresis with sodium dodecylsulfate before and after reduction with 2-mercaptoethanol. The patient met European League against Rheumatism (EULAR) criteria for scleroderma.

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The carboxylic acid derivatives, aldehydes, and ketones prepared in this way are important intermediates in the manufacture of dyes, pharmaceuticals, agrochemicals, and other industrial products. Glycated albumin modulates platelet susceptibility to flow induced activation and aggregation. In 2001, we surveyed generalist and specialist physicians serving commercial, Medicaid, and Medicare patients. The aim of this study was to analyse the trends and socio-economic inequalities in the use of health care services in Spain between 1993 and 2006. Non-muscle myosin II isoforms thus appear to have distinct enzymatic properties that may be of importance in carrying out their cellular functions.

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pseudotuberculosis infection by secreting TNF-alpha and IFN-gamma. Gastric intramucosal acidosis in mechanically ventilated patients: role of mucosal blood flow.

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Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets. Univariate and multiple linear regression analysis identified being women, type and quality of denture, having little knowledge on implants and being hospitalised as the risk factors for refusing implants.

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To investigate multiple slice computed tomography (MSCT) and magnetic resonance imaging (MRI) features of congenital stenosis of the internal auditory canal (CSIAC) and improve the ability for diagnosis. Six-month-old calves were inoculated with 200 metacercariae of Fasciola hepatica over a 72 day period. Few days before the admittance in our ward, he experienced fever, anorexia, and severe dispnoea. Diacylglycerol kinase (DGK) terminates diacylglycerol (DAG) signaling by phosphorylating DAG to produce phosphatidic acid, which also has signaling properties. In 1994, Switzerland introduced experimental heroin assisted treatment for refractory opioid addicts as last line of treatment.

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Further studies are needed to determine whether the use of rapid diagnostic tests improves outcomes in returning travelers with suspected malaria. The purification and structural elucidation of bradykinin--a reminiscence of 1960. Folding of human telomerase RNA pseudoknot using ion-jump and temperature-quench simulations.

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There are few case control studies of abused and non-abused children where standard terminology, examination method and description allow for meaningful comparison. Institutionalised racism lies at the heart of the conceptual systems we use in psychiatry. However, a non-infectious approach that controls allergic responses might represent a safer and more promising strategy. Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state. The APUD concept has postulated that pulmonary carcinoids and small cell carcinomas arise from the neural crest.

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Twenty-four parturient women from three governmental medical training centers in Isfahan, Iran were recruited using purposive sampling. To investigate whether wastewater workers are at increased risk of developing cancer.

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Residual ethmoid cells (RECs), which result from failure to completely remove them, have been thought to be a cause of recurrence of CRS. Our objective was to evaluate the effect of routine use of the umbilical Doppler in unselected or low risk pregnancies by reviewing all published and unpublished randomised controlled trials. Superoxide is generated in response to a secreted factor during the transition to the multicellular phase of development. Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors. However, large sample sizes are required to detect any differences in outcomes between antimicrobials in clinical trials, and, generally, studies are powered to show only clinical equivalence.

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To determine the effect of external vascular compression on distal perfusion, the authors attempted to occlude vessels with subcutaneous hyaluronic acid gel (HAG) bolus injections into the pinna of hairless mice. One patient developed a prelaryngeal soft tissue recurrence and retained his larynx after wide local excision and radiotherapy. Wound healing parameters were assessed in the inflammatory, proliferative, and remodeling phases of healing. SDS-PAGE analysis also revealed an additional protein of 18 kDa, which was equal l azel active professional to the putative tyrosinase according to the size of mel fragment, was expressed in the E. In this paper we describe the complete sequence of this clone, which has been designated CYP71B7 in accordance with the nomenclature for the cyt P450 gene superfamily.

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Less glycogen utilization in CAL hearts during ischaemia may contribute to increased ischaemic tolerance by limiting ischaemic proton production that may improve ion homeostasis during early reperfusion. Surgically managed perinatal testicular torsion: a single centre experience. Periorbital edema secondary to positive airway pressure therapy. In case of a fetal ventral abdominal wall defect, the detection and appropriate classification of associated fetal tenofovir disoproxil fumarate lamivudine efavirenz tablets side effects anomalies is of great importance for the further course of pregnancy.

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The strategy included replacement of cysteine residues and screening for periplasmic expression followed by random mutagenesis and phage display selection with a conformation-specific anti-DHPS antibody. The aim of the present study was to neurochemically characterize the superficial nerves in the vulvar vestibular mucosa of women with VVS. To evaluate the efficacy diclofenac sodium paracetamol and chlorzoxazone tablets used for abm of laparoscopic sleeve gastrectomy(LSG) on improving glycemic control of morbidly obese patients with type 2 diabetes mellitus.

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A bioassay for possible carcinogenicity of technical-grade trifluralin was conducted using Osborne-Mendel rats and B6C3F1 mice. The data are consistent with a role of brain 5HT neurons modifenac 75 mg bivirkninger prednisolone in the adrenalectomy-induced triphasic changes in ACTH secretion. Physical capacity and risk for long-term sickness absence: a prospective cohort study among 8664 female health care workers. A correlation between the severity of disease and pig age was observed.

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A reduction in the time spent in hospital limits the time available for consultation between patients and hospital staff. This review considers the central role of the T cell in this group of disorders and provides a comprehensive overview of recent studies that elucidate our understanding of the mechanisms involved in the pathogenesis of food allergy in regard to the role of the T cell. Novel and recurrent mutations in the C-terminal domain of COMP cluster in two distinct regions and result in a spectrum of phenotypes within the pseudoachondroplasia -- multiple epiphyseal dysplasia disease group. They may also have a role in maintaining peripheral tolerance to alprazolam 0.25 mg dose side effects self-antigens by initiating an immune response only in the context of danger signals released from cells during stress, damage or death.

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